Since HYDRNOL refers to a class of similar but different molecules, there is no single answer for how each will be made cheaply and efficiently. Several are based on petroleum by-products, some are alcohol based (ethanol and butanol feed stocks,) and others would be best made in plants specializing in fertilizer production.

All the methods used to make the original HYDRNOL molecule are based on well-known process chemistry. The cost of the original molecule is not terribly important, since it will be recycled 100 times or more.